Nose infection side effect of metformin12/29/2023 who have heart failure (when the heart cannot pump enough blood to the rest of your body) to reduce the risk of cardiovascular death and hospitalization for heart failure.who have known cardiovascular disease to reduce the risk of cardiovascular death.One of the medicines in SYNJARDY and SYNJARDY XR, empagliflozin (JARDIANCE), can also be used in adults with type 2 diabetes: SYNJARDY and SYNJARDY XR can be used along with diet and exercise to improve blood sugar in adults with type 2 diabetes. The most common side effects of KOMBIGLYZE XR include upper respiratory tract infection, stuffy or runny nose and sore throat, urinary tract infection, headache, diarrhea, and nausea and vomiting.SYNJARDY and SYNJARDY XR are prescription medicines that contains 2 diabetes medicines, empagliflozin (JARDIANCE) and metformin hydrochloride. Swallow KOMBIGLYZE XR whole do not crush, cut, or chew if you will be starting or stopping certain other types of medicines, such as antibiotics, or medicines that treat fungus or HIV/AIDS, as your doctor may need to change your dose of KOMBIGLYZE XR.if you are pregnant, breast-feeding, or plan to become pregnant or breast-feed.Tell your doctor right away if you develop blisters or the breakdown of the outer layer of your skin Some people who take medicines called DPP-4 inhibitors, like one of the active ingredients in KOMBIGLYZE XR, may develop a skin reaction called bullous pemphigoid that can require treatment in a hospital. Call your doctor if you have severe joint pain Some people who take medicines called DPP-4 inhibitors, one of the medicines in KOMBIGLYZE XR, may develop joint pain that can be severe. Follow your doctor's instructions for treating low blood sugar Symptoms of low blood sugar include, shaking, sweating, rapid heartbeat, change in vision, hunger, headache and change in mood. If you take KOMBIGLYZE XR with another medicine that can cause low blood sugar (hypoglycemia), such as sulfonylureas or insulin, you have a higher risk of having low blood sugar. Contact your doctor right away if you have any of the following symptoms of heart failure: increasing shortness of breath or trouble breathing, especially when you lie down an unusually fast increase in weight swelling or fluid retention, especially in the feet, ankles or legs unusual tiredness Before taking KOMBIGLYZE XR tell your doctor if you have ever had heart failure or problems with your kidneys. The pain may happen with or without vomiting. The pain may be felt going from your abdomen through to your back. Stop taking KOMBIGLYZE XR and contact your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. Before taking KOMBIGLYZE XR, tell your doctor if you ever had pancreatitis, gallstones, history of alcoholism, or high triglyceride levels. Inflammation of the pancreas (pancreatitis) which may be severe and lead to death.Serious side effects can happen in people who take KOMBIGLYZE XR, including: If you have any of these symptoms, stop taking KOMBIGLYZE XR and contact your healthcare provider or go to the nearest hospital emergency room right away Symptoms of a serious allergic reaction may include: swelling of the face, lips or throat, difficulty swallowing or breathing, swelling of the skin, hives, rash, itching, flaking, or peeling. are allergic to saxagliptin, metformin, or any of the ingredients in KOMBIGLYZE XR.Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with KOMBIGLYZE XR Tell your doctor if you have any of the following, because you have a higher chance for getting lactic acidosis with KOMBIGLYZE XR if you have severe kidney problems, your kidneys are affected by certain x-ray tests that use injectable dye, have liver problems, drink alcohol (very often or a lot of alcohol in short-term “binge” drinking), get dehydrated (lose a large amount of body fluids), have surgery, have a heart attack, severe infection, or stroke. Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Call your doctor right away if you have any of the following symptoms, which could be signs of lactic acidosis: feel cold in your hands or feet, feel dizzy or lightheaded, have a slow or irregular heartbeat, feel very weak or tired, unusual (not normal) muscle pain, trouble breathing, feel sleepy or drowsy, or have stomach pains, nausea or vomiting. Lactic acidosis is a medical emergency and must be treated in the hospital. Metformin, one of the medicines in KOMBIGLYZE XR, can cause a rare, but serious, condition called lactic acidosis (a build-up of an acid in the blood) that can cause death. KOMBIGLYZE XR can cause serious side effects, including lactic acidosis. Important Safety Information Important Safety Information
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